منابع مشابه
Regulation of hematopoiesis: helper and suppressor influences of the thymus.
Thymocytes from normal mice strains as well as from genetically determined stem cell defective W/Wv anemic mice were cocultured with syngeneic (or congeneic) bone marrow cells. We assayed these cocultures for the proliferation of erythroid progenitor cell types (BFU-E and CFU-E) using the plasma clot technique. Results indicate that when concentrations of thymocytes were lower than bone marrow ...
متن کاملSeparation of Helper a N D Suppressor T Lymphocytes
The existence of subpopulations of T cells has been recognized in a number of experimental models. Raft and Cantor (1) first subdivided T cells into T1 and T2 according to an antigen-driven maturation scheme. T1 cells which were immature, short-lived, and noncirculating upon encounter with antigens developed into mature T~ cells which were long-lived, circulating, and had a lower density of Thy...
متن کامل1358 Helper and Suppressor T Cell Activation by Pvp
Type 2 antigens such as polyvinylpyrrolidone (PVP), 1 type III pneumococcal polysaccharide ($3), and dinitrophenyl (DNP)-ficoll characteristically elicit antibody responses in mice that consist almost entirely of antibodies of the IgM and IgG3 isotypes (1-4). Type 2 antigens also are generally unable to prime mice to produce I gG 1 and IgG2 antibodies after secondary challenge, i.e. they are un...
متن کاملSeparation of helper and suppressor T lymphocytes. II. Ly phenotypes and lack of DNA synthesis requirement for the generation of concanavalin A helper and suppressor cells
Using a Ficoll velocity sedimentation gradient, we have been able to fractionate concanavalin A (Con A)-induced helper and suppressor cells into separate pools. Cells activated by Con A to mediate helper activity are Ly1+, do not require DNA synthesis for induction, and remain as small cells after activation. Suppressor cells are Ly23+, are found in the blast cell fraction and their induction i...
متن کاملSeparation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses
Concanavalin A, a nonspecific polyclonal activator of T lymphocytes, activates Lyl and Ly23 subclasses to the same degree. After activation, the Ly23 subclass, but not the Lyl subclass, has the following properties: (a) Suppression of the antibody response to sheep erythrocytes (SRBC) in vitro. (b) Production of a soluble factor that suppresses the anti-SRBC response in vitro. (c) Suppression o...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2004
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2004.00442.x